The last year of the 5th age. Most of the events of Runescape happen, done by the Hero of Ashdale. River of Blood takes place, as well as the assault on the Judge's fortress just prior.
Three years past the events of the World Wakes. The gods have returned and are gathering their armies. The Myreque are no more, and there is a tenuous peace in Morytania kept by a ruling council of humans, icyene, and vampyres.
For all intents and purposes, unless you make plans with other characters, characters haven't seen one another in three years.
Calsidiu disappeared after River of Blood and has not been seen nor heard from since.
The Judge has been working in tandem with various vampyric forces such as house Foryx, who actively detest the new icyenic/human ruling of morytania, but his actual actions have been kept strictly secret.
Proteus and Gwendolyn are still missing, presumed officially dead three years after their capture in the failed assault.
Constance, after the failed assault on The Judge, vanished, presumably being captured and tortured to death.
Strife left morytania for a short while in an attempt to gather aid for the Myreque's cause.
Marko, after several years at the Void Knight Outpost, is said to be soon returning to the rather empty Burgh De Rott.
Draven was never allowed to rejoin the Myreque, as shortly after his exulsion the group disbanded. He is believed to currently be with his tribe.
Atticus, upon realizing that the myreque were truly no more, headed off west to start some kind of group of thugs and mercs.
The Helix continued their efforts to reinforce paterdomus and ensure that things flowed peacefully in morytania. They also provided shelter to anyone who was left with noone to go to and nowhere to go.